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Stat Med 2008;27:157–172. Zethelius B, Berglund L, Sundstrom J, et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 2008;358:2107– 2116. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983;148:839 – 843. 16. 17. 18. 19. 20. Levy DE, Brott TG, Haley ECJ, et al. Factors related to intracranial hematoma formation in patients receiving tissue-type plasminogen activator for acute ischemic stroke.
LMNA and VAPB loci were also excluded. Based on our extensive clinical assessment and the performed molecular genetic analyses, the disease in the 2 families we report may represent a new type of late-onset autosomal dominant lower motor neuron disease/SMA. The similarity of clinical features in the 2 families and the fact that they originate from the same geographic region suggests they may have the same disease, but this cannot be fully settled without further genetic evidence. AUTHOR CONTRIBUTIONS Dr.
008, at 3 months of follow-up). Conclusions: This study showed a significant protective association of SCH with better outcomes and lower mortality after cerebral ischemic stroke. Possible explanations for this association are ischemic preconditioning, reduced adrenergic tone, and hypometabolic state. Neurology® 2011; 77:349–354 GLOSSARY mRS ϭ modified Rankin Scale; NIHSS ϭ NIH Stroke Scale; SCH ϭ subclinical hypothyroidism; T3 ϭ triiodothyronine; T4 ϭ thyroxine; TSH ϭ thyroid-stimulating hormone; WBC ϭ white blood cell.