Advances in Immunology, Vol. 53 by Frank J. Dixon (Ed.)

By Frank J. Dixon (Ed.)

For 30 years, this esteemed serial has supplied scholars and researchers with the most recent info in Immunology. you could proceed to depend upon Advances in Immunology to supply you with serious experiences that study topics of significant significance to the sphere via precis and assessment of present wisdom and learn. The articles tension primary options, but additionally overview the experimental ways. each one quantity of Advances in Immunology incorporates a topic index in addition to the contents of modern volumes. every one bankruptcy comprises references. Researchers and scholars in microbiology, genetics and immunocology will use this beneficial serial to stick up-to-date at the newest advances for years yet to come. Key good points * Advances in Immunology will retain you knowledgeable on such generally outlined topics as: * Immunochemistry * Antibody synthesis * organic motion of antibodies * Immunological unresponsiveness * Mechanisms in innate and bought immunity no longer regarding antibodies * really expert immunological suggestions

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However, since cDNAs for the various cytokines were first cloned and expressed it has become obvious that few are specific to one target cell and fewer still are unique in function. , induction of proliferation, on another cell target. , that of inhibiting the growth of tumor cells, was unlikely to correspond to an endogenous response by the body to reject tumor cells. More likely the effect on tumor cells reflected some function on normal cells. The subject of this review, the leukemia inhibitory factor (LIF), exemplifies many features of cytokine biology.

A,, Evely, R. , Cough, N . , Ng, K. , Nicola, N. , and Martin, T. J. (1990). Osteoblasts display receptors for and responses to leukemia-inhibitory factor. J . Cell. Physiol. 145, 110-1 19. , and Burgess, A. W. (1991). Stimulation of niyoblast proliferation in culture by leukemia inhibitory factor and other cytokines. J . Neurol. Sci. 10, 193-197. Bard, J. , and Ross, A. S. (1991). LIF, the ES-cell inhibition factor, reversibly blocks nephrogenesis in cultured mouse kidney rudiments. Deueloprnent 113, 193-198.

135,3796, 87. Seder, R. , Paul, W. , Davis, hl. , and Fazekas de St. Groth, B. (1992). The presence of IL-4 during i i i citro priming deterniines the lymphokine-producirig potential of CD4' T cells from T cell receptor transgenic mice. J . E x ) ) . Med. 176, 1091. 88. , Heimberger, A. , Gold, J. , and Murphy, K. M. (1992). Differential regulation o f T helper phenotype development by interleukins 4 and 10 in an ah T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. 89,6065. 88a. , and Paul, W.

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