Adenosine and Adenine Nucleotides: From Molecular Biology to by Marlene A. Jacobson (auth.), Luiz Belardinelli, Amir Pelleg

By Marlene A. Jacobson (auth.), Luiz Belardinelli, Amir Pelleg (eds.)

This booklet features a choice of lectures given throughout the fifth overseas Symposium on Adenosine and Adenine Nucleotides, lately held in Philadelphia, Pennsylvania.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology covers quite a lot of topics from molecular and mobile biology to scientific functions. a very good emphasis has been put on leading edge info derived from stories utilizing molecular and mobile biology thoughts utilized to the sector of adenosine and adenine nucleotide study. The booklet additionally comprises details on in all probability promising advancements within the healing purposes of adenosine similar medications and ATP. The culture of previous conferences is additionally maintained through together with within the software displays of recent learn within the components of purine metabolism and body structure, and pharmacology of adenosine and adenine nucleotides.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology is a superb, updated reference e-book for simple and scientific scientists within the box of adenosine and adenine nucleotides.

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Bruns RF, Lu GH, Pugsley TA (1986) Characterization of the Az adenosine receptor labeled by eH}NECA in rat striatal neurons. Mol PharmacoI29:331-346. Stehle ]H, Rivkees SC, Lee J], Weaver DR, Deeds ]D, Reppert SM (1992) Molecular cloning and expressin of the eDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol 6:384-393. Zhou Q-Y, Li C, Olah ME, Johnson RA, Stiles GL, Civelli 0 (1992) Molecular cloning and characterization of an adenosine receptor: The A3 adenosine receptor. Proc Nat!

The rat brain A3 receptor cloned by Stiles and coworkers {21] had 58% sequence homology with the dog Al and A2 receptors {7J and was identical in structure to a previously isolated Gprotein-coupled receptor (GPCR), tgpcrl, found in the testis. The rat A3 receptor was unique for a PI purinoceptor in that radioligand binding was insensitive to xanthine blockade. The subsequent cloning of the A3 receptor from sheep {25} and human {26J brain showed that in these species this receptor was sensitive to acidic xanthines.

Finally, Ser281 and the 5' -OH group of the ribose moiety appear to interact, again via hydrogen bonding. In contrast, the hydrophobic cyclohexyl group of SHA 174 is indeed in a lipophilic environment. 5 A. A comparison of the two binding sites reveals that corresponding amino acids in the receptor models are involved. This is evident from Figure 4-5A, in which the receptor bound conformations of CPA and SHA 174 show a great deal of overlap. DOCKING OF ANTAGONISTS How might the potent and A I-selective antagonist 1, 3-dipropyl-8-cyclopentylxanthine (DPCPX; Fig.

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