A user's guide to the human genome by Wolfsberg Tyra G., Wetterstrand Kris A., Guyer Mark S.,

By Wolfsberg Tyra G., Wetterstrand Kris A., Guyer Mark S., Collins Francis S., Baxevanis Andreas D.

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Extra info for A user's guide to the human genome

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To obtain more details on this hit, click the details link, to the left of the entry. A long web page is returned, with three major sections: the mRNA sequence (Fig. 5, top), the genomic sequence (Fig. 5, middle) and an alignment of the mRNA sequence against the genomic sequence (see Fig. 9 for an example). In the alignment in Fig. 5, matching bases in the cDNA and genomic sequences are colored in darker blue and capitalized. Gaps are indicated in lower-case black type. Light blue upper-case bases mark the boundaries of aligned regions on either side of a gap and are often splice sites.

Edu), click on Browser in the blue sidebar on the left-hand side of the page, and set the Genome Browser Gateway to a region of interest. For example, one could set the genome to Human and the assembly to Dec. 2001, type chr22:38496887-39496866 into the position box, and click Submit to display a representative region of the December 2001 assembly of human chromosome 22. A number of tracks are already displayed in dense format (Fig. 1). Below the graphic showing the specified region are pull-down menus that allow the user to change the appearance of the graphic, under the heading Track Controls (Fig.

Most of the methods show a 3′ untranslated region, indicated by the heavy, shorter block at the left of the predictions. The Acembly track shows three possible alternative splices in addition to the full-length product shown in the third line of that section, a prediction that agrees with those shown in most of the other tracks. The Genscan track extends off to both the right and the left: GENSCAN can be used to predict multiple genes, and this display implies that the method has been applied in this fashion.

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